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The suggested dithiol mechanism was based on experiments at a single substrate concentration that required more than 8 h for redox equilibration in the presence of 0.5 M glutaredoxin with or without 1 M GSH

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J Med Chem 58(18):73707380 Agerso H et al (2002) The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men

2014 Aug 15;289(33):23065-74